Peyronie's disease occurs when a buildup of scar tissue causes curved and often painful erections. Learn the symptoms, causes, and treatment options. Learn about Peyronie’s disease, the causes, how it develops, the risk factors, diagnosis, and treatment options, and clinical trials. Learn more about the diagnosis and treatment of Peyronie's disease. Find tips to get ready for any appointments you need. Peyronie's disease is a condition in which scar tissue that develops in the penis causes a curved, painful erection. Learn about symptoms and treatment. Peyronie's (pay-roe-NEEZ) disease is a condition in which fibrous scar tissue forms in the deeper tissues under the skin of the penis. This causes curved, painful erections. It also can make the penis shorter while erect. Peyronie's disease is not caused by cancer. Penises vary in shape and size. Peyronie’s disease causes your penis to curve due to plaque build-up under your skin. You can treat this condition with injections, oral medications, and, in severe cases, surgery. Peyronie’s disease is a condition where the penis develops a curve due to scar tissue, leading to pain and possible erectile dysfunction. Treatment options include penile traction therapy and injections to break down scar tissue. Peyronie's disease (PD) is a benign, acquired penile connective tissue disease characterized by the occurrence of fibrotic plaques within the tunica albuginea —the dense elastic covering of the corpora cavernosa. What is Peyronie’s disease? Peyronie’s (pay-roe-NEEZ) disease is a condition in which scar tissue (plaque) in your penis causes it to bend, curve or lose length or girth (circumference). You may be able to feel the scar tissue through your skin, or you may have pain in a specific part of your penis as the scar tissue forms. Peyronie’s disease is a connective tissue disorder of the penis that can be likened to Dupuytren’s contracture of the hand. It is characterized by the triad of bent erections, pain in the penis with erections and palpable penile plaque.